5-Ethynylpyridin-2-amine → HCID 67000406, compound

HRID 558929Notes

Reaction equation

HRID 558929 reaction equation
I[C:2]1[CH:3]=[N:4][N:5]2[CH:10]=[CH:9][C:8]([C:11]3[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=3)=[N:7][C:6]=12.[C:21]([C:23]1[CH:24]=[CH:25][C:26]([NH2:29])=[N:27][CH:28]=1)#[CH:22]>>[F:18][C:17]([F:20])([F:19])[C:14]1[CH:15]=[CH:16][C:11]([C:8]2[CH:9]=[CH:10][N:5]3[N:4]=[CH:3][C:2]([C:22]#[C:21][C:23]4[CH:24]=[CH:25][C:26]([NH2:29])=[N:27][CH:28]=4)=[C:6]3[N:7]=2)=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 219548275-Ethynylpyridin-2-amineHCID 67000994HCID 67000994, compound

Product 1

HCID 67000406HCID 67000406, compound

Procedure

The title compound was prepared from 3-iodo-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.33 step 1) (195 mg, 0.5 mmol) and 5-ethynyl-pyridin-2-ylamine (example D.1) (59 mg, 0.5 mmol) according to general procedure II. Obtained as an orange solid (101 mg, 53%). MS (ISP) 380.0 [(M+H)+]; mp 213-214° C.

Sources & evidence

ORD record
ord-d9d245d984f748ebad75e4eaa6910e51
Source dataset
uspto-grants-2011_11
Patent number
US08063048B2

Reaction notes

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