Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Azobisisobutyronitrile → Methyl 4-(bromomethyl)-3-chlorobenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Azobisisobutyronitrile | HCID 6547 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | Methyl 3-Chloro-4-methylbenzoate | HCID 2801405 | — |
| 용매 | Carbon Tetrachloride | HCID 5943 | — |
| 생성물 | Methyl 4-(bromomethyl)-3-chlorobenzoate | HCID 22027761 | — |
반응 단계
To a solution of methyl 3-chloro-4-methylbenzoate (5.0 g, 27.1 mmol) in carbon tetrachloride (50 ml) were added NBS (5.8 g, 32.0 mmol) and AIBN (0.442 g, 2.70 mmol). The mixture was stirred at reflux for 18 h. The mixture was allowed to cool to room temperature and then concentrated in vacuo. The residue was purified by flash chromatography on silica (eluant EtOAc:pet. ether 0:100 to 5:95); yield 5.96 g (84%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08063038B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-8adbeaccfcbe4b69bbc402efd4baee10 |
| 출처 메모 | uspto-grants-2011_11 |