反应详情

To a degassed solution of (2-fluoro-6-nitrophenylamino)acetic acid ethyl ester from Example B2 (2.1 g, 8.7 mmol) in methanol (65 ml) was added palladium on carbon (10%, 600 mg). Hydrogen gas was bubbled through the mixture for 75 mins, filtered through Celite® and reduced in vacuo. The residues was purified by flash chromatography on silica (eluant EtOAc: pet. ether 50:50); yield 1.02 g, 71%.

1. customHydrogen gas was bubbled through the mixture for 75 mins
2. filtrationfiltered through Celite®
3. customThe residues was purified by flash chromatography on silica (eluant EtOAc: pet. ether 50:50)