反应详情

温度

180 °C

Compound 66 (150 mg, 0.524 mmol) and N-(4-morpholin-4-yl-phenyl)-guanidine were dissolved in EtOH (4 mL). The mixture was then stirred at 180° C. in the microwave for 30 minutes. The solvent was evaporated in vacuo and the residue diluted with MeOH (50 mL). The solution was heated to 60° C. on a rotary evaporator with swirling. The solution was cooled to rt and the solvent carefully decanted. The process was repeated twice more. The residual solvent was then evaporated in vacuo. The title compound was afforded as a yellow solid (110 mg, 47%); LCMS, Rt=2.58 min (MeOH-FA method), m/z 444 (MH+).

1. customThe solvent was evaporated in vacuo
2. additionthe residue diluted with MeOH (50 mL)
3. temperatureThe solution was heated to 60° C. on a rotary evaporator
4. temperatureThe solution was cooled to rt
5. customthe solvent carefully decanted
6. customThe residual solvent was then evaporated in vacuo