HRID558959

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21

HCID159087

Triacetoxyperiodinane

C13H13IO8

结构：Cc1cc(C(=O)N2CCCCc3ccccc32)ccc1CNC(=O)N1CC(=O)N(CCO)c2cccc(F)c21

HCID11548258

未命名化合物

PRODUCTS

生成物

HCID11533826

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To a solution of 8-fluoro-4-(2-hydroxyethyl)-3-oxo-3,4-dihydro-2H-quinoxaline-1-carboxylic acid 2-methyl-4-(2,3,4,5-tetrahydrobenzo[b]azepine-1-carbonyl)benzylamide from Example 9 (105 mg, 0.20 mmol) in dichloromethane (5 ml) was added Dess-Martin periodinane (100 mg, 0.24 mg). The mixture was stirred for 2 h and evaporated. The residue was taken up in chloroform and water and separated. The organic layer was dried and evaporated. The residue was purified by flash chromatography on silica (eluant methanol:dichloromethane 4:96) to give a white solid; yield 73 mg, 69%.

WORKUP

后处理

customevaporated
customwater and separated
customThe organic layer was dried
customevaporated
customThe residue was purified by flash chromatography on silica (eluant methanol:dichloromethane 4:96)
customto give a white solid

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4cec32232e0c435b9517a04fff59cd4a
来源数据集: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08063038B2
来源说明: uspto-grants-2011_11

反应 SMILES

[CH3:1][C:2]1[CH:26]=[C:25]([C:27]([N:29]2[CH2:35][CH2:34][CH2:33][CH2:32][C:31]3[CH:36]=[CH:37][CH:38]=[CH:39][C:30]2=3)=[O:28])[CH:24]=[CH:23][C:3]=1[CH2:4][NH:5][C:6]([N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][C:16]=2[F:18])[N:11]([CH2:19][CH2:20][OH:21])[C:10](=[O:22])[CH2:9]1)=[O:7].CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O>ClCCl>[CH3:1][C:2]1[CH:26]=[C:25]([C:27]([N:29]2[CH2:35][CH2:34][CH2:33][CH2:32][C:31]3[CH:36]=[CH:37][CH:38]=[CH:39][C:30]2=3)=[O:28])[CH:24]=[CH:23][C:3]=1[CH2:4][NH:5][C:6]([N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][C:16]=2[F:18])[N:11]([CH2:19][CH:20]=[O:21])[C:10](=[O:22])[CH2:9]1)=[O:7]