HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide dimethyl acetal → 3-Chloro-6-(-3-dimethylamino-acryloyl)-pyridine-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | 6-Acetyl-3-chloropyridine-2-carbonitrile | HCID 90356694 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-Chloro-6-(-3-dimethylamino-acryloyl)-pyridine-2-carbonitrile | HCID 118620027 | 35% |
Reaction Steps
Compound 64 (633 mg, 2.7 mmol) and N,N-dimethylformamide dimethyl acetal (1.1 mL, 8.1 mmol) in toluene was heated to reflux for 5 h. After which time the solvent was evaporated and the crude product triturated with isoxane/diethylether to give compound 67 as an orange solid (222 mg, 35%); LCMS Rt=2.35 min (MeOH-FA method), m/z 236 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09433622B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-d8324f398a0c4032b9f244b496ce199f |
| Source note | uspto-grants-2016_09 |