反应详情

Compound 80 (252 mg, 0.5 mmol) was dissolved in 1:1 2 M HCl-MeCN and the reaction mixture stirred at rt for 5 hours. The solvent was removed in vacuo and the residue triturated with 9:1 EtOAc-MeOH to afford the title compound (152 mg, 79%) as a dark yellow solid; LCMS, Rt=2.40 min (MeOH-FA method), m/z 392 (MH+).

1. customThe solvent was removed in vacuo
2. customthe residue triturated with 9:1 EtOAc-MeOH