Imidazole → 1-(2-fluoro-4-nitrophenyl)-1H-imidazole

Participants

Role	Name	HCID	Charge
Reactant	Imidazole	HCID 795	—
Reactant	Water	HCID 962	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	1,2-Difluoro-4-nitrobenzene	HCID 123053	—
Solvent	Dimethylformamide	HCID 6228	—
Product	1-(2-fluoro-4-nitrophenyl)-1H-imidazole	HCID 5306153	96.8%

Reaction Steps

A mixture of 3,4-difluoronitrobenzene (1.00 mL, 9.03 mmol), imidazole (0.615 g, 9.04 mmol) and K2CO3 (2.50 g, 18.1 mmol) in DMF (10 mL) was stirred at room temperature overnight. Water (20 mL) was added to induce precipitation. The precipitate was collected, dried on vacuum to give 1-(2-fluoro-4-nitrophenyl)-1H-imidazole as a solid (1.81 g). MS 208.2 (M+H)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08063058B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-4b20f4cebb9d42299be69da5564c8cf7
Source note	uspto-grants-2011_11