3-(Pyrrolidin-1-yl)aniline → 2-((1R,2S)-2-aminocyclohexylamino)-4-(3-(pyrrolidin-1-yl)phenylamino)pyrimidine-5-carboxamide

HRID 559035Notes

Reaction equation

HRID 559035 reaction equation
[NH2:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:9]1[N:14]=[C:13](NC2C=CC(C3ON=CC=3)=CC=2)[C:12]([C:27]([NH2:29])=[O:28])=[CH:11][N:10]=1.[N:30]1([C:35]2[CH:36]=[C:37]([CH:39]=[CH:40][CH:41]=2)[NH2:38])[CH2:34][CH2:33][CH2:32][CH2:31]1>>[NH2:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:9]1[N:14]=[C:13]([NH:38][C:37]2[CH:39]=[CH:40][CH:41]=[C:35]([N:30]3[CH2:31][CH2:32][CH2:33][CH2:34]3)[CH:36]=2)[C:12]([C:27]([NH2:29])=[O:28])=[CH:11][N:10]=1

Participants

3

Reactant 2

HCID 15188083-(Pyrrolidin-1-yl)anilineHCID 461846122-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[4-(1,2-oxazol-5-yl)anilino]pyrimidine-5-carboxamide

Product 1

HCID 574719022-((1R,2S)-2-aminocyclohexylamino)-4-(3-(pyrrolidin-1-yl)phenylamino)pyrimidine-5-carboxamide

Procedure

This compound was synthesised using the synthetic scheme described for the synthesis of compound 122, and using 3-(pyrrolidin-1-yl)aniline in step 1. MS: 396.6 (M+H).

Workup

  1. customThis compound was synthesised

Sources & evidence

ORD record
ord-8e28d72f80da44f6ae57474979ace8e7
Source dataset
uspto-grants-2011_11
Patent number
US08063058B2

Reaction notes

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