Lithium Hydroxide → HCID 25072121, compound

Participants

Reaction Steps

An aqueous LiOH solution (2N, 0.08 mL) was added to a stirring solution of example 31 (10 mg, 0.021 mmol) in MeOH (0.15 mL). The reaction mixture was stirred at r.t. for 2 h. Purification by preparative HPLC mass triggered gave 0.4 mg (4%) of the title compound as a light yellow solid. 1H NMR (400 MHz, CDCl3): δ 14.29 (s, 1H), 11.06 (s, 1H), 8.47 (s, 1H), 7.51-7.56 (m, 2H), 7.17 (t, 1H, J=8.4 Hz), 5.73 (s, 1H), 3.95 (s, 3H), 3.63 (s, 3H). MS (ES) [m+H] calc'd for C17H13FIN3O4, 470; found 470.

Provenance & Evidence