反应详情

温度

80 °C

2.7 g of sodium acetate are added to a solution of 5 g of 4-cyanophenylhydrazine hydrochloride in 40 ml of acetic acid and the mixture is then heated at 80° C. for 20 hours. The reaction mixture is concentrated under vacuum, the residue is taken up with water, the product is extracted with EtOAc, the organic phase is washed with a saturated NaCl solution and dried over MgSO4, and the solvent is evaporated off under vacuum. The residue is triturated in a PE/EtOAc (90/10; v/v) mixture and the precipitate formed is filter-dried. 4.8 g of the expected compound are obtained.

1. concentrationThe reaction mixture is concentrated under vacuum
2. extractionthe product is extracted with EtOAc
3. washthe organic phase is washed with a saturated NaCl solution
4. dry with materialdried over MgSO4
5. customthe solvent is evaporated off under vacuum
6. customThe residue is triturated in a PE/EtOAc (90/10; v/v) mixture
7. customthe precipitate formed
8. customis filter-dried