2-(2-Bromoethoxy)tetrahydro-2H-pyran → HCID 66997900, compound

HRID 559147Notes

Reaction equation

HRID 559147 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:28](=[O:29])[N:27]([CH3:30])[C:12]2[N:13]([CH3:26])[C:14]3[C:19]([C:11]=2[CH:10]=1)=[CH:18][C:17]([C:20]1[NH:21][N:22]=[C:23](C)[CH:24]=1)=[CH:16][CH:15]=3.Br[CH2:32][CH2:33][O:34][CH:35]1[CH2:40][CH2:39][CH2:38][CH2:37][O:36]1>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:28](=[O:29])[N:27]([CH3:30])[C:12]2[N:13]([CH3:26])[C:14]3[C:19]([C:11]=2[CH:10]=1)=[CH:18][C:17]([C:20]1[CH:24]=[CH:23][N:22]([CH2:32][CH2:33][O:34][CH:35]2[CH2:40][CH2:39][CH2:38][CH2:37][O:36]2)[N:21]=1)=[CH:16][CH:15]=3

Participants

3

Reactant 2

HCID 866212-(2-Bromoethoxy)tetrahydro-2H-pyranHCID 178422591HCID 178422591, compound

Product 1

HCID 66997900HCID 66997900, compound

Procedure

The process is carried out as indicated in Example 36 above, using 3-(2,4-dichlorophenyl)-1,9-dimethyl-6-(5-methyl-2H-pyrazol-3-yl)-1,9-dihydropyrido[2,3-b]indol-2-one described in Example 39 and 2-(2-bromoethoxy)tetrahydropyran (Collect. Czech. Chem. Commun.; EN; 69; 10; 2004; 1843-1876).

Sources & evidence

ORD record
ord-3d14ea930f5d420082d889c2f4807038
Source dataset
uspto-grants-2011_11
Patent number
US08063061B2

Reaction notes

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