Ethoxyacetic acid → HCID 66998296, compound

Participants

Reaction Steps

756 mg (1.73 mmol) of compound 6-(aminoacetyl)-3-(2,4-dichlorophenyl)-1-methyl-1,9-dihydro-2H-pyrido[2,3-b]indol-2-one hydrochloride from Example 5A above, 180 μl (1.90 mmol) of ethoxyacetic acid, 991 mg (1.90 mmol) of PyBOP and 905 μl (5.2 mmol) of diisopropylethylamine are dissolved in 9 ml of CH2Cl2. The mixture is stirred at ambient temperature for 16 h. A saturated solution of NH4Cl is added and the mixture is extracted with CH2Cl2, dried over MgSO4, filtered and concentrated under vacuum. The product is purified by chromatography on a silica column, elution being carried out with EtOAc and then EtOAc/3% MeOH.

Provenance & Evidence