反应详情

930 mg (1.85 mmol) of compound A 4-[3-(2,4-dichlorophenyl)-1,9-dimethyl-2-oxo-2,9-dihydro-1H-pyrido[2,3-b]indol-6-yl]-2,4-dioxobutyric acid ethyl ester are dissolved in 20 ml of absolute ethanol. 583 mg (5.56 mmol) of ethylhydrazine oxalate are added and the mixture is refluxed overnight. The reaction medium is evaporated to dryness and the residue is triturated in a saturated K2CO3 solution. The product is filtered and washed with water. Purification is carried out on a silica column, elution being carried out with EtOAc.

1. temperaturethe mixture is refluxed overnight
2. customThe reaction medium is evaporated to dryness
3. customthe residue is triturated in a saturated K2CO3 solution
4. filtrationThe product is filtered
5. washwashed with water
6. customPurification
7. washis carried out on a silica column, elution