Diisopropylethylamine → HCID 66998399, compound

Participants

Reaction Steps

500 mg (1.11 mmol) of 6-(aminoacetyl)-3-(2,4-dichlorophenyl)-1,9-dimethyl-1,9-dihydro-2H-pyrido[2,3-b]indol-2-one, hydrochloride described in Example 18A above, 175 μL (1.22 mmol) of benzyloxyacetic acid, 635 mg (1.22 mmol) of PyBop and 580 μL (3.33 mmol) of diisopropylethylamine are dissolved in 6 ml of CH2Cl2. The mixture is stirred at ambient temperature for 16 h. A saturated NH4CL solution is added, the mixture is then extracted with CH2CL2 and the organic phase is dried over MgSO4, filtered and concentrated under vacuum. Purification is carried out on a silica column, elution being carried out with EtOAc and then with EtOAc/5% MeOH. 454 mg of yellow crystals are obtained.

Provenance & Evidence