HCID 86623952, compound → HCID 66998231, compound

Participants

Reaction Steps

370 mg (0.73 mmol) of compound B 6-(4-azidomethylthiazol-2-yl)-3-(4-bromophenyl)-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one are dissolved in 40 ml of methanol and 40 ml of glacial acetic acid. 40 mg of Pd/C are added. The mixture is hydrogenated under 60 psi at 25° C. for 48 hours. The reaction medium is filtered over celite. Washing is carried out with ethanol. The filtrate is evaporated to dryness. The residue is dissolved in a CH2Cl2/MeOH mixture and the product is adsorbed onto silica. Purification is carried out on a silica column, elution being carried out with 97/02/01 CH2Cl2/MeOH/NH4OH and then with 93/05/02 CH2Cl2/MeOH/NH4OH.

Provenance & Evidence