ethyl 2-((tetrahydro-2H-pyran-2-yl)oxy)acetate → 1-[3-(2,4-Dichlorophenyl)-1,9-dimethyl-2-oxo-2,9-dihydro-1H-pyrido[2,3-b]indol-6-yl]-4-(tetrahydropyran-2-yloxy)butane-1,3-dione

Participants

Role	Name	HCID	Charge
Reactant	ethyl 2-((tetrahydro-2H-pyran-2-yl)oxy)acetate	HCID 10899396	—
Reactant	6-acetyl-3-(2,4-dichlorophenyl)-1,9-dimethyl-1,9-dihydro-2H-pyrido[2,3-b]indol-2-one	HCID 66997309	—
Product	1-[3-(2,4-Dichlorophenyl)-1,9-dimethyl-2-oxo-2,9-dihydro-1H-pyrido[2,3-b]indol-6-yl]-4-(tetrahydropyran-2-yloxy)butane-1,3-dione	HCID 66997467	—

Reaction Steps

The process is carried out as in Example 80 above, with the compound from preparation 1.10E, 6-acetyl-3-(2,4-dichlorophenyl)-1,9-dimethyl-1,9-dihydro-2H-pyrido[2,3-b]indol-2-one and (tetrahydropyran-2-yloxy)acetic acid ethyl ester.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08063061B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-4298017115e34b7d840cf9b7628d816f
Source note	uspto-grants-2011_11