Water → HCID 66997922, compound

Participants

Reaction Steps

460 mg (1.09 mmol) of compound from Example 37 above, 3-(2,4-dichlorophenyl)-1-methyl-6-(1-methyl-1H-pyrazol-3-yl)-1,9-dihydro-2H-pyrido[2,3-b]indol-2-one are dissolved in 50 ml of CH2Cl2. 576 mg (5.43 mmol) of CNBr, 44 mg (0.36 mmol) of DMAP and then 308 μl (2.17 mmol) of triethylamine are added. The mixture is stirred at ambient temperature for 18 h. H2O is added, the mixture is extracted with CH2Cl2, and the organic phase is dried over MgSO4, filtered and concentrated, and purification is carried out on a silica column, elution being carried out with EtOAc/50% cyclohexane.

Provenance & Evidence