Sulfuric Acid → HCID 66998161, compound

HRID 559199Notes

Reaction equation

HRID 559199 reaction equation
OS(O)(=O)=O.[CH2:6]([O:8][C:9](=[O:40])[C:10](=O)[CH2:11][S:12][C:13]([C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][CH:23]=1)[N:20]([CH3:24])[C:19]1[N:25]([CH3:38])[C:26](=[O:37])[C:27]([C:29]3[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][C:30]=3[Cl:36])=[CH:28][C:18]2=1)=[NH:14])[CH3:7].[OH-].[Na+]>O>[CH2:6]([O:8][C:9]([C:10]1[N:14]=[C:13]([C:15]2[CH:16]=[C:17]3[C:21](=[CH:22][CH:23]=2)[N:20]([CH3:24])[C:19]2[N:25]([CH3:38])[C:26](=[O:37])[C:27]([C:29]4[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][C:30]=4[Cl:36])=[CH:28][C:18]3=2)[S:12][CH:11]=1)=[O:40])[CH3:7]

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 66998271HCID 66998271, compound

Product 1

HCID 66998161HCID 66998161, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3 ml of H2SO4 are added to compound A, 3-[3-(2,4-dichlorophenyl)-1,9-dimethyl-2-oxo-2,9-dihydro-1H-pyrido[2,3-b]indole-6-carboximidoylsulphanyl]-2-oxopropionic acid ethyl ester obtained above and the mixture is stirred at ambient temperature for 16 h. 15 ml of H2O and 5 ml of 1M NaOH are added. The mixture is extracted with EtOAC and concentrated without drying over MgSO4.

Workup

  1. customobtained above and the mixture
  2. extractionThe mixture is extracted with EtOAC
  3. concentrationconcentrated
  4. dry with materialwithout drying over MgSO4

Sources & evidence

ORD record
ord-1f555b15c2854a4f853f380da9f1efd3
Source dataset
uspto-grants-2011_11
Patent number
US08063061B2

Reaction notes

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