Sodium Hydroxide → HCID 66997921, compound

Participants

Reaction Steps

A solution containing 218 mg (0.43 mmol) of compound B, 2-[3-(2,4-dichlorophenyl)-1,9-dimethyl-2-oxo-2,9-dihydro-1H-pyrido[2,3-b]indol-6-yl]thiazole-4-carboxylic acid ethyl ester in 8 ml of CH2Cl2 is refluxed. 430 μl (0.85 mmol) of 2M LiBH4 in THF are added. The mixture is refluxed for 16 h. The reaction medium is left to cool, 10 ml of 1M NaOH are added and the reaction medium is concentrated to dryness. The residue is taken up in H2O, filtered and then washed with H2O and then with MeOH.

Provenance & Evidence