1-(2-Chloroethyl)pyrrolidine → 3-(2,4-Dichlorophenyl)-6-[2-ethyl-5-(2-pyrrolidin-1-yl-ethoxymethyl)-2H-pyrazol-3-yl]-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one hydrochloride

HRID 559209Notes

Reaction equation

HRID 559209 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:31](=[O:32])[N:30]([CH3:33])[C:12]2[N:13]([CH3:29])[C:14]3[C:19]([C:11]=2[CH:10]=1)=[CH:18][C:17]([C:20]1[N:21]([CH2:27][CH3:28])[N:22]=[C:23]([CH2:25][OH:26])[CH:24]=1)=[CH:16][CH:15]=3.Cl[CH2:35][CH2:36][N:37]1[CH2:41][CH2:40][CH2:39][CH2:38]1>>[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:31](=[O:32])[N:30]([CH3:33])[C:12]2[N:13]([CH3:29])[C:14]3[C:19]([C:11]=2[CH:10]=1)=[CH:18][C:17]([C:20]1[N:21]([CH2:27][CH3:28])[N:22]=[C:23]([CH2:25][O:26][CH2:35][CH2:36][N:37]2[CH2:41][CH2:40][CH2:39][CH2:38]2)[CH:24]=1)=[CH:16][CH:15]=3

Participants

3

Reactant 2

HCID 816691-(2-Chloroethyl)pyrrolidineHCID 669985353-(2,4-Dichlorophenyl)-6-(2-ethyl-5-hydroxymethyl-2H-pyrazol-3-yl) 1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one

Product 1

HCID 669980983-(2,4-Dichlorophenyl)-6-[2-ethyl-5-(2-pyrrolidin-1-yl-ethoxymethyl)-2H-pyrazol-3-yl]-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one hydrochloride

Procedure

The process is carried out as in Example 101 above, with the compound from Example 61, 3-(2,4-dichlorophenyl)-6-(2-ethyl-5-hydroxymethyl-2H-pyrazol-3-yl)-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one and chloroethylpyrrolidine.

Sources & evidence

ORD record
ord-eba30245dff14783989b5b0621ac56cc
Source dataset
uspto-grants-2011_11
Patent number
US08063061B2

Reaction notes

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