Propionyl chloride → 3-(4-Fluorophenyl)-1,9-dimethyl-6-propionyl-1,9-dihydropyrido[2,3-b]indol-2-one

HRID 559213Notes

Reaction equation

HRID 559213 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:21](=[O:22])[N:20]([CH3:23])[C:11]3[N:12]([CH3:19])[C:13]4[C:18]([C:10]=3[CH:9]=2)=[CH:17][CH:16]=[CH:15][CH:14]=4)=[CH:4][CH:3]=1.[C:24](Cl)(=[O:27])[CH2:25][CH3:26]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:21](=[O:22])[N:20]([CH3:23])[C:11]3[N:12]([CH3:19])[C:13]4[C:18]([C:10]=3[CH:9]=2)=[CH:17][C:16]([C:24](=[O:27])[CH2:25][CH3:26])=[CH:15][CH:14]=4)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 62324Propionyl chlorideHCID 154067853-(4-Fluorophenyl)-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one

Product 1

HCID 669984293-(4-Fluorophenyl)-1,9-dimethyl-6-propionyl-1,9-dihydropyrido[2,3-b]indol-2-one

Procedure

The process is carried out as indicated in preparation 1.1E above, with compound from Example 63A, 3-(4-fluorophenyl)-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one and propionyl chloride

Sources & evidence

ORD record
ord-87fd4c4e967d438e89cb3a32ce302648
Source dataset
uspto-grants-2011_11
Patent number
US08063061B2

Reaction notes

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