Bromomethyl methyl ether → HCID 16226479, compound

HRID 559215Notes

Reaction equation

HRID 559215 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:27](=[O:28])[N:26]([CH3:29])[C:11]3[N:12]([CH3:25])[C:13]4[C:18]([C:10]=3[CH:9]=2)=[CH:17][C:16]([C:19]2[NH:20][N:21]=[CH:22][C:23]=2[CH3:24])=[CH:15][CH:14]=4)=[CH:4][CH:3]=1.[CH3:30][O:31][CH2:32]Br>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:27](=[O:28])[N:26]([CH3:29])[C:11]3[N:12]([CH3:25])[C:13]4[C:18]([C:10]=3[CH:9]=2)=[CH:17][C:16]([C:19]2[C:23]([CH3:24])=[CH:22][N:21]([CH2:30][O:31][CH3:32])[N:20]=2)=[CH:15][CH:14]=4)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 83093Bromomethyl methyl etherHCID 66997872HCID 66997872, compound2×

Product 1

HCID 16226479HCID 16226479, compound

Procedure

The process is carried out as in Example 36 above, using compound from Example 112, 3-(4-fluorophenyl)-1,9-dimethyl-6-(4-methyl-2H-pyrazol-3-yl)-1,9-dihydropyrido[2,3-b]indol-2-one and bromomethyl methyl ether.

Sources & evidence

ORD record
ord-725ed50530c747b08dcb99ef9f3854cd
Source dataset
uspto-grants-2011_11
Patent number
US08063061B2

Reaction notes

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