Thiourea → 6-(2-Aminothiazol-4-yl)-3-(4-fluorophenyl)-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one

HRID 559220Notes

Reaction equation

HRID 559220 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[N:10]([CH3:14])[C:9]1[N:15]([CH3:27])[C:16](=[O:26])[C:17]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)=[CH:18][C:8]2=1)=O.[NH2:28][C:29]([NH2:31])=[S:30]>>[NH2:31][C:29]1[S:30][CH:2]=[C:3]([C:5]2[CH:6]=[C:7]3[C:11](=[CH:12][CH:13]=2)[N:10]([CH3:14])[C:9]2[N:15]([CH3:27])[C:16](=[O:26])[C:17]([C:19]4[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=4)=[CH:18][C:8]3=2)[N:28]=1

Participants

3

Reactant 2

HCID 2723790ThioureaHCID 866239516-(2-Bromoacetyl)-3-(4-fluorophenyl)-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one

Product 1

HCID 866239566-(2-Aminothiazol-4-yl)-3-(4-fluorophenyl)-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one

Procedure

The process is carried out as for Example 21 above, using compound A, 6-(2-bromoacetyl)-3-(4-fluorophenyl)-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one and thiourea.

Sources & evidence

ORD record
ord-034139e5e779465c8e6751f0a2b572c2
Source dataset
uspto-grants-2011_11
Patent number
US08063061B2

Reaction notes

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