Hydrochloric Acid → HCID 66998714, compound

Participants

Reaction Conditions

Reaction Steps

100 mg (0.2 mmol) of compound A, 6-(5-chloromethyl-1-methyl-1H-pyrazol-3-yl)-3-(2,4-dichlorophenyl)-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one are dissolved in 5 ml of anhydrous DMF. 55 mg (0.4 mmol) of K2CO3 and 22 μl (0.25 mmol) of morpholine are added. The mixture is heated at 80° C. overnight. It is allowed to return to ambient temperature and poured into water. The mixture is extracted with EtOAc. The organic phase is washed with a saturated NaCl solution. It is dried over Na2SO4, filtered and evaporated to dryness. Purification is carried out on a silica column, elution being carried out with a 95/05 EtOAc/MeOH mixture. The product obtained is dissolved in EtOAc and 0.5 ml of a saturated solution of HCl in Et2O/petroleum ether is added. The precipitate formed is filtered off and washed with ether. The product is taken up in MeOH and evaporated to dryness.

Provenance & Evidence