Chloromethyl ethyl ether → 3-(2,4-dichlorophenyl)-6-(1-ethoxymethyl-1H-pyrazol-3-yl)-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one

HRID 559247Notes

Reaction equation

HRID 559247 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:27](=[O:28])[N:26]([CH3:29])[C:12]2[N:13]([CH3:25])[C:14]3[C:19]([C:11]=2[CH:10]=1)=[CH:18][C:17]([C:20]1[CH:24]=[CH:23][NH:22][N:21]=1)=[CH:16][CH:15]=3.[CH2:30]([O:32][CH2:33]Cl)[CH3:31]>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:27](=[O:28])[N:26]([CH3:29])[C:12]2[N:13]([CH3:25])[C:14]3[C:19]([C:11]=2[CH:10]=1)=[CH:18][C:17]([C:20]1[CH:24]=[CH:23][N:22]([CH2:33][O:32][CH2:30][CH3:31])[N:21]=1)=[CH:16][CH:15]=3

Participants

3

Reactant 2

HCID 18523Chloromethyl ethyl etherHCID 178481367HCID 178481367, compound

Product 1

HCID 669980763-(2,4-dichlorophenyl)-6-(1-ethoxymethyl-1H-pyrazol-3-yl)-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one

Procedure

The process is carried out as in Example 36 above with the compound from Example 39, 3-(2,4-dichlorophenyl)-1,9-dimethyl-6-(1H-pyrazol-3-yl)-1,9-dihydropyrido[2,3-b]indol-2-one and chloromethyl ethyl ether.

Sources & evidence

ORD record
ord-9982a4559d024fc9a4dabd9a6bbf9147
Source dataset
uspto-grants-2011_11
Patent number
US08063061B2

Reaction notes

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