(2-Methoxyethyl)thiourea → 3-(2,4-Dichlorophenyl)-6-[2-(2-methoxyethylamino)thiazol-4-yl]-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one

HRID 559254Notes

Reaction equation

HRID 559254 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[N:10]([CH3:14])[C:9]1[N:15]([CH3:28])[C:16](=[O:27])[C:17]([C:19]3[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=3[Cl:26])=[CH:18][C:8]2=1)=O.[CH3:29][O:30][CH2:31][CH2:32][NH:33][C:34]([NH2:36])=[S:35]>>[Cl:26][C:20]1[CH:21]=[C:22]([Cl:25])[CH:23]=[CH:24][C:19]=1[C:17]1[C:16](=[O:27])[N:15]([CH3:28])[C:9]2[N:10]([CH3:14])[C:11]3[C:7]([C:8]=2[CH:18]=1)=[CH:6][C:5]([C:3]1[N:36]=[C:34]([NH:33][CH2:32][CH2:31][O:30][CH3:29])[S:35][CH:2]=1)=[CH:13][CH:12]=3

Participants

3

Reactant 2

HCID 1810725(2-Methoxyethyl)thioureaHCID 866239506-(bromoacetyl)-3-(2,4-dichlorophenyl)-1,9-dimethyl-1,9-dihydro-2H-pyrido[2,3-b]indol-2-one

Product 1

HCID 866239573-(2,4-Dichlorophenyl)-6-[2-(2-methoxyethylamino)thiazol-4-yl]-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one

Procedure

The process is carried out as for Example 21 above, using the compound from preparation 1.2, 6-(bromoacetyl)-3-(2,4-dichlorophenyl)-1,9-dimethyl-1,9-dihydro-2H-pyrido[2,3-b]indol-2-one and 1-(2-methoxyethyl)-2-thiourea.

Sources & evidence

ORD record
ord-2867e09e35c14bd9b021560fb6fbfc7f
Source dataset
uspto-grants-2011_11
Patent number
US08063061B2

Reaction notes

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