tert-Butoxy bis(dimethylamino)methane → 3-(2,4-dichlorophenyl)-9-difluoromethyl-6-((E)-3-dimethylaminoacryloyl)-1-methyl-1,9-dihydropyrido[2,3-b]indol-2-one

HRID 559256Notes

Reaction equation

HRID 559256 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH:13]([F:15])[F:14])[C:8]1[N:16]([CH3:29])[C:17](=[O:28])[C:18]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][C:21]=3[Cl:27])=[CH:19][C:7]2=1)(=[O:3])[CH3:2].CC(O[CH:35](N(C)C)[N:36]([CH3:38])[CH3:37])(C)C>>[Cl:27][C:21]1[CH:22]=[C:23]([Cl:26])[CH:24]=[CH:25][C:20]=1[C:18]1[C:17](=[O:28])[N:16]([CH3:29])[C:8]2[N:9]([CH:13]([F:15])[F:14])[C:10]3[C:6]([C:7]=2[CH:19]=1)=[CH:5][C:4]([C:1](=[O:3])/[CH:2]=[CH:35]/[N:36]([CH3:38])[CH3:37])=[CH:12][CH:11]=3

Participants

3

Reactant 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 669974346-Acetyl-3-(2,4-dichlorophenyl)-9-difluoromethyl-1-methyl-1,9-dihydropyrido[2,3-b]indol-2-one

Product 1

HCID 669979273-(2,4-dichlorophenyl)-9-difluoromethyl-6-((E)-3-dimethylaminoacryloyl)-1-methyl-1,9-dihydropyrido[2,3-b]indol-2-one

Procedure

The process is carried out as for preparation 1.10 above, using compound A: 6-acetyl-3-(2,4-dichlorophenyl)-9-difluoromethyl-1-methyl-1,9-dihydropyrido[2,3-b]indol-2-one and Bredereck's reagent.

Workup

  1. customThe process is carried out as for preparation 1.10 above,

Sources & evidence

ORD record
ord-289a0ecc58ae4ccc8a39496f5c4b1d86
Source dataset
uspto-grants-2011_11
Patent number
US08063061B2

Reaction notes

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