HCID 86623958, compound → HCID 66997418, compound

HRID 559259Notes

Reaction equation

HRID 559259 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:29](=[O:30])[N:28]([CH3:31])[C:12]2[N:13]([CH3:27])[C:14]3[C:19]([C:11]=2[CH:10]=1)=[CH:18][C:17]([C:20]1[N:21]=[C:22]([CH:25]=[O:26])[S:23][CH:24]=1)=[CH:16][CH:15]=3.[CH3:32][Mg]Br>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:29](=[O:30])[N:28]([CH3:31])[C:12]2[N:13]([CH3:27])[C:14]3[C:19]([C:11]=2[CH:10]=1)=[CH:18][C:17]([C:20]1[N:21]=[C:22]([CH:25]([OH:26])[CH3:32])[S:23][CH:24]=1)=[CH:16][CH:15]=3

Participants

3

Reactant 2

HCID 86623958HCID 86623958, compoundHCID 178418573HCID 178418573, compound

Product 1

HCID 66997418HCID 66997418, compound

Procedure

The process is carried out as indicated in Example 139 above, with compound A, 4-[3-(2,4-dichlorophenyl)-1,9-dimethyl-2-oxo-2,9-dihydro-1H-pyrido[2,3-b]indol-6-yl]-thiazole-2-carbaldehyde, and methylmagnesium bromide.

Sources & evidence

ORD record
ord-6c414e8680034fa39374d32c339edbc3
Source dataset
uspto-grants-2011_11
Patent number
US08063061B2

Reaction notes

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