3,3,3-Trifluoropropionyl chloride → 3-(2,4-Dichlorophenyl)-1,9-dimethyl-6-[1-(3,3,3-trifluoropropionyl)-1H-pyrazol-3-yl]-1,9-dihydropyrido[2,3-b]indol-2-one

HRID 559270Notes

Reaction equation

HRID 559270 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:27](=[O:28])[N:26]([CH3:29])[C:12]2[N:13]([CH3:25])[C:14]3[C:19]([C:11]=2[CH:10]=1)=[CH:18][C:17]([C:20]1[CH:24]=[CH:23][NH:22][N:21]=1)=[CH:16][CH:15]=3.[F:30][C:31]([F:37])([F:36])[CH2:32][C:33](Cl)=[O:34]>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:27](=[O:28])[N:26]([CH3:29])[C:12]2[N:13]([CH3:25])[C:14]3[C:19]([C:11]=2[CH:10]=1)=[CH:18][C:17]([C:20]1[CH:24]=[CH:23][N:22]([C:33](=[O:34])[CH2:32][C:31]([F:37])([F:36])[F:30])[N:21]=1)=[CH:16][CH:15]=3

Participants

3

Reactant 2

HCID 27833433,3,3-Trifluoropropionyl chlorideHCID 178481367HCID 178481367, compound

Product 1

HCID 669984873-(2,4-Dichlorophenyl)-1,9-dimethyl-6-[1-(3,3,3-trifluoropropionyl)-1H-pyrazol-3-yl]-1,9-dihydropyrido[2,3-b]indol-2-one

Procedure

The process is carried out as indicated in Example 70 above, with the compound from Example 39 3-(2,4-dichlorophenyl)-1,9-dimethyl-6-(1H-pyrazol-3-yl)-1,9-dihydropyrido[2,3-b]indol-2-one and 3,3,3-trifluoropropionyl chloride.

Sources & evidence

ORD record
ord-bee048440e6f416cb6d31db2369322dc
Source dataset
uspto-grants-2011_11
Patent number
US08063061B2

Reaction notes

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