Sodium Hydroxide → HCID 178488037, compound

Participants

Reaction Steps

8.7 g of sodium hydroxide and 175 ml of methanol were taken into a round bottom flask and stirred for 15 minutes. A solution of 50 g of esomeprazole dissolved in 175 ml of methanol was added to the above methanolic sodium hydroxide. The mixture was stirred at 29° C. for 3.5 hours. The mixture was then distilled atmospherically at 78° C. to remove 80% of the solvent. 250 ml of ethyl acetate was added to the residue and was co-distilled with 750 ml of ethyl acetate in three equal lots at 40° C. To the obtained residue, another 250 ml of ethyl acetate was added and stirred at 29° C. for 1 hour. The separated solid was filtered and washed with 100 ml of ethyl acetate. The wet compound was taken into another round bottom flask and 250 ml of ethyl acetate was added and stirred for 1 hour, 15 minutes. The separated solid was filtered and washed with 100 ml of ethyl acetate. The wet compound was dried at 62° C. for 6 hours to yield 51.2 g of the title compound.

Provenance & Evidence