Sodium Hydroxide → HCID 178488037, compound

HRID 559275Notes

Reaction equation

HRID 559275 reaction equation
[OH-].[Na+:2].[CH3:3][C:4]1[CH:5]=[N:6][C:7]([CH2:13][S+:14]([O-:26])[C:15]2[NH:16][C:17]3[CH:18]=[CH:19][C:20]([O:24][CH3:25])=[CH:21][C:22]=3[N:23]=2)=[C:8]([CH3:12])[C:9]=1[O:10][CH3:11]>CO>[CH3:3][C:4]1[CH:5]=[N:6][C:7]([CH2:13][S+:14]([O-:26])[C:15]2[N-:16][C:17]3[CH:18]=[CH:19][C:20]([O:24][CH3:25])=[CH:21][C:22]=3[N:23]=2)=[C:8]([CH3:12])[C:9]=1[O:10][CH3:11].[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium Hydroxide2×HCID 178488147HCID 178488147, compound

Product 1

HCID 178488037HCID 178488037, compoundYield 79.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

2.31 g of sodium hydroxide and 70 ml of methanol were taken into a round bottom flask and stirred for dissolution. A solution of 20 g of esomeprazole in 70 ml of methanol was added to the above methanolic sodium hydroxide. The mixture was stirred at 30° C. for 3.5 hours. The mixture was then distilled using a flash distillation technique at 30° C. to obtain 16.8 g of the title compound.

Workup

  1. stirringThe mixture was stirred at 30° C. for 3.5 hours
  2. distillationThe mixture was then distilled
  3. distillationa flash distillation technique at 30° C.

Sources & evidence

ORD record
ord-a2e1bb1c10e242948af9d0df2b02256d
Source dataset
uspto-grants-2011_11
Patent number
US08063074B2

Reaction notes

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