Trifluoroacetic acid → 5-carboxymethoxy-3-(1-naphthoyl)-N-pentyl-1H-indole

Participants

Reaction Steps

To a solution of 7 (3.0 g, 6 4 mmol) in dichloromethane (50 ml) was added TFA (25 ml) and the mixture was stirred at room temperature for 3 h. The mixture was evaporated to dryness and the crude obtained was purified by chromatography on silica-gel using 5% methanol in chloroform to give Hapten-B (2.1 g, 79%).

Provenance & Evidence