Trifluoroacetic acid → HCID 66999727, compound

Participants

Reaction Steps

To a stirred solution of {4-[(3RS,4SR)-3-[(SR)-1-(5-cyano-pyridin-2-yloxy)-ethyl]-4-(3,4-dichloro-phenyl)-pyrrolidine-1-carbonyl]-cyclohexyl}-methyl-carbamic acid tert-butyl ester described herein above (30 mg, 0.050 mmol) in CH2Cl2 (4 mL) was added TFA (1 mL). After 1 hour, aqueous NaHCO3 was added until ph=8, the product was extracted with CH2Cl2. The combined organic phases were dried over Na2SO4 to give the title product as a colorless oil (25 mg, 98%). ES-MS m/e: 500.9 (M+H+).

Provenance & Evidence