HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → (4S)-6-Azaspiro[2.5]octan-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Product | (4S)-6-Azaspiro[2.5]octan-4-ol | HCID 44541813 | — |
Reaction Steps
The title compound was treated with di-tert-butyl-dicarbonate in methanol in the presence of triethylamine. The crude tert-butoxycarbonyl-protected amine product was analyzed by chiral GC (BGB-176; 30 m×0.25 mm; 80° C. to 210° C. in 43 min) and proved to be identical with intermediate 25b.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063042B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-bf418f2836dd4c3f8687426e0d324a04 |
| Source note | uspto-grants-2011_11 |