HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-1-(3-Benzyloxy-propyl)-3-methyl-piperazin-2-one → (S)-1-(3-Hydroxy-propyl)-3-methyl-piperazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-1-(3-Benzyloxy-propyl)-3-methyl-piperazin-2-one | HCID 66999230 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (S)-1-(3-Hydroxy-propyl)-3-methyl-piperazin-2-one | HCID 66999467 | 99% |
Reaction Steps
A solution of (S)-1-(3-benzyloxy-propyl)-3-methyl-piperazin-2-one (9.07 g, 34.6 mmol) in methanol only heated for 14 h at 70° C. under a hydrogen atmosphere (7 bar) in the presence of palladium (10% on activated charcoal, 7.36 g). After cooling, insoluble material was removed by filtration and the filtrate evaporated to produce the title compound (5.90 g, 99%). Colorless oil, MS (ISP)=173.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063042B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-c07b8a5db5e64407afdf512dd13a48c1 |
| Source note | uspto-grants-2011_11 |