HCID 66999754, compound → HCID 66999588, compound

Participants

Reaction Steps

A solution of (R)-2-benzyloxymethyl-3-oxo-4-(3-piperidin-1-yl-propyl)-piperazine-1-carboxylic acid tert-butyl ester (321 mg, 0.72 mmol) in acetic acid (9 ml) was stirred for 18 h at room temperature under a hydrogen atmosphere (3 bar) in the presence of palladium (10% on activated charcoal, 161 mg), then insoluble material was removed by filtration and the filtrate evaporated. The residue was partitioned between ethyl acetate and 2 M aq. sodium carbonate solution. The organic layer was dried (MgSO4), filtered, and evaporated to afford the title compound (200 mg, 78%). Light brown oil, MS (ISP)=356.4 (M+H)+.

Provenance & Evidence