Triethylamine → 4-[(E)-3-(3-Chloro-4-fluoro-phenyl)-acryloyl]-1-[3-((3S,4S)-3-hydroxy-4 methyl-piperidin-1-yl)-propyl]-3-methyl-piperazin-2-one

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	3-(3-Chloro-4-fluorophenyl)prop-2-enoic acid	HCID 2773644	—
Reactant	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
Reactant	1-[3-((3S,4S)-3-hydroxy-4-methyl-piperidin-1-yl)-propyl]-3-methyl-piperazin-2-one dihydrochloride	HCID 66999280	—
Solvent	Dimethylformamide	HCID 6228	—
Product	4-[(E)-3-(3-Chloro-4-fluoro-phenyl)-acryloyl]-1-[3-((3S,4S)-3-hydroxy-4 methyl-piperidin-1-yl)-propyl]-3-methyl-piperazin-2-one	HCID 57550375	—

Reaction Steps

To a solution of crude 1-[3-((3S,4S)-3-hydroxy-4-methyl-piperidin-1-yl)-propyl]-3-methyl-piperazin-2-one dihydrochloride (example 41; 0.03 mg, 0.1 mmol) in N,N-dimethylformamide (0.8 ml) was added 3-chloro-4-fluorocinnamic acid (0.02 g, 0.1 mmol), triethylamine (0.05 ml, 0.4 mmol) and O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluoro-phosphate (0.04 g, 0.1 mmol) and the reaction shaken for 1 h, after which time the reaction mixture was directly purified by preparative HPLC. This afforded the titled product as a colorless gum. MS (ISP)=452.2 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08063042B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-5d731b75b8dc4aea9029aeac27e3c1bd
Source note	uspto-grants-2011_11