N-(2-iodophenyl)methanesulfonamide → 1-Chloro-2-(1-methanesulfonyl-1H-indol-2-yl)-propan-2-ol

HRID 55942Notes

Reaction equation

HRID 55942 reaction equation
I[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][S:9]([CH3:12])(=[O:11])=[O:10].[Cl:13][CH2:14][C:15]([CH3:19])([OH:18])[C:16]#[CH:17]>>[Cl:13][CH2:14][C:15]([C:16]1[N:8]([S:9]([CH3:12])(=[O:11])=[O:10])[C:3]2[C:2]([CH:17]=1)=[CH:7][CH:6]=[CH:5][CH:4]=2)([OH:18])[CH3:19]

Participants

3

Reactant 2

HCID 780001N-(2-iodophenyl)methanesulfonamideHCID 124238571-Chloro-2-methylbut-3-yn-2-ol

Product 1

HCID 115147621-Chloro-2-(1-methanesulfonyl-1H-indol-2-yl)-propan-2-ol

Procedure

This compound was prepared using the general Sonagashira procedure as described in General Example C, from N-(2-iodo-phenyl)-methanesulfonamide (1.65 g, 5.55 mmol) and 1-chloro-2-methyl-but-3-yn-2-ol (0.79 g, 6.66 mmol) to yield a brown oil.

Workup

  1. customThis compound was prepared
  2. customto yield a brown oil

Sources & evidence

ORD record
ord-1b10ee023d8049e7a7889c8ec1ceab95
Source dataset
uspto-grants-2016_09
Patent number
US09434688B2

Reaction notes

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