4-Bromo-2-fluorotoluene → HCID 67001587, compound

HRID 559482Notes

Reaction equation

HRID 559482 reaction equation
[C:1]([O:5][C:6]([NH:8][C@@H:9]1[CH2:13][CH2:12][NH:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Br[C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[C:17]([F:22])[CH:16]=1>>[C:1]([O:5][C:6](=[O:7])[NH:8][C@@H:9]1[CH2:13][CH2:12][N:11]([C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[C:17]([F:22])[CH:16]=2)[CH2:10]1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 1710404-Bromo-2-fluorotolueneHCID 1514397(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine

Product 1

HCID 67001587HCID 67001587, compound

Procedure

The title compound was prepared from (3R)(+)-3-(tert-butoxycarbonylamino)pyrrolidine and 4-bromo-2-fluorotoluene using the procedure outlined for Description 11.

Sources & evidence

ORD record
ord-43974a9d1b1341458f0d269ded2722a2
Source dataset
uspto-grants-2011_11
Patent number
US08063078B2

Reaction notes

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