o-Fluorobenzaldehyde → HCID 57456783, compound

Participants

Reaction Conditions

Reaction Steps

2-Fluorobenzaldehyde (7.45 g), was added to aminoacetaldehyde diethylacetal (9.16 g) and the reaction heated to 100° C. for 3 h. After cooling, the mixture was transferred to a separating funnel and partitioned between diethyl ether and water. The ether layer was separated, dried over magnesium sulfate, filtered and concentrated under reduced pressure to leave an oil. Distillation at 0.6-0.8 mm collecting the fraction boiling at 102-106° C. afforded the title compound as a colourless oil.

Provenance & Evidence