HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethylsulfanyl-but-3-yn-2-ol → 2-ethylsulfanyl-1-(1-methanesulfonyl-5-nitro-6-trifluoromethyl-1H-indol-2-yl)-ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethylsulfanyl-but-3-yn-2-ol | HCID 58979594 | — |
| Reactant | N-[2-Iodo-4-nitro-5-(trifluoromethyl)phenyl]methanesulfonamide | HCID 58979620 | — |
| Product | 2-ethylsulfanyl-1-(1-methanesulfonyl-5-nitro-6-trifluoromethyl-1H-indol-2-yl)-ethanol | HCID 11502477 | — |
Reaction Steps
This compound was prepared using the general Sonagashira procedure as described in General Procedures Example C, starting from N-(2-iodo-4-nitro-5-trifluoromethyl-phenyl)-methanesulfonamide (1.89 g, 4.6 mmol) and 1-ethylsulfanyl-but-3-yn-2-ol (0.6 g, 4.6 mmol), reacted to yield the title compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434688B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-8947db5d1a0841a6bc90eedb40c37d8c |
| Source note | uspto-grants-2016_09 |