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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 55949Generated: October 28, 2026

1-Ethylsulfanyl-but-3-yn-2-ol → 2-ethylsulfanyl-1-(1-methanesulfonyl-5-nitro-6-trifluoromethyl-1H-indol-2-yl)-ethanol

https://huagongshe.com/reaction/55949

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Ethylsulfanyl-but-3-yn-2-olHCID 58979594—
ReactantN-[2-Iodo-4-nitro-5-(trifluoromethyl)phenyl]methanesulfonamideHCID 58979620—
Product2-ethylsulfanyl-1-(1-methanesulfonyl-5-nitro-6-trifluoromethyl-1H-indol-2-yl)-ethanolHCID 11502477—

Reaction Steps

This compound was prepared using the general Sonagashira procedure as described in General Procedures Example C, starting from N-(2-iodo-4-nitro-5-trifluoromethyl-phenyl)-methanesulfonamide (1.89 g, 4.6 mmol) and 1-ethylsulfanyl-but-3-yn-2-ol (0.6 g, 4.6 mmol), reacted to yield the title compound as a yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09434688B2
Source datasetuspto-grants-2016_09
ORD IDord-8947db5d1a0841a6bc90eedb40c37d8c
Source noteuspto-grants-2016_09