Ammonia → HCID 85978227, compound

HRID 559490Notes

Reaction equation

HRID 559490 reaction equation
Cl.C(O[C:5](=[NH:21])[C:6]1[CH:11]=[CH:10][C:9]([S:12](=[O:20])(=[O:19])[NH:13][C:14]2[S:15][CH:16]=[CH:17][N:18]=2)=[CH:8][CH:7]=1)C.[NH3:22]>>[S:15]1[CH:16]=[CH:17][N:18]=[C:14]1[NH:13][S:12]([C:9]1[CH:8]=[CH:7][C:6]([C:5]([NH2:21])=[NH:22])=[CH:11][CH:10]=1)(=[O:19])=[O:20]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 86611694HCID 86611694, compound

Product 1

HCID 85978227HCID 85978227, compound

Procedure

A solution of 4-(thiazol-2-ylsulfamoyl)-benzimidic acid ethyl ester hydrochloride (100 mmol) in 7 N NH3 (120 mL in methanol) was stirred at 60° C. for 2 h. After reaction mixture was cooled to room temperature, the precipitate was filtered, washed with methanol, and dried in vacuo to give a quantitative yield of 4-(thiazol-2-ylsulfamoyl)-benzamidine.

Workup

  1. customAfter reaction mixture
  2. filtrationthe precipitate was filtered
  3. washwashed with methanol
  4. customdried in vacuo

Sources & evidence

ORD record
ord-5ecb1ebba31b4e2085442867c95626e1
Source dataset
uspto-grants-2011_11
Patent number
US08063080B2

Reaction notes

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