Chloromethyl Methyl Ether → HCID 67000857, compound

Participants

Reaction Steps

To a suspension of NaH (1.1 mmol in 60% mineral oil) in THF (3 mL) at 0° C. was added 3-(4-bromo-phenyl)-5-(3-chloro-benzyl)-4H-[1,2,4]triazole (1.0 mmol). After the mixture was stirred for 30 min, MOMCl (1.0 mmol) was added and the mixture was stirred from 0° C. to room temperature overnight. The reaction mixture was diluted with EtOAc, washed with brine, dried over MgSO4, and concentrated in vacuo. The crude product was purified by column chromatography to give 3-(4-bromo-phenyl)-5-(3-chloro-benzyl)-4-methoxymethyl-4H-[1,2,4]triazole and 5-(4-bromo-phenyl)-3-(3-chloro-benzyl)-1-methoxymethyl-1H-[1,2,4]triazole (0.75 mmol) as a mixture of two isomers (4:1).

Provenance & Evidence