2,6-Dichlorophenylacetamidine → 4-[2-(2,6-dichloro-benzyl)-3H-imidazol-4-yl]-N-methoxymethyl-N-thiazol-2-yl-benzenesulfonamide

Participants

Reaction Steps

A solution of 4-(2-bromo-acetyl)-N-methoxymethyl-N-thiazol-2-yl-benzenesulfonamide (0.062 mmol) and the free base of 2-(2,6-dichloro-phenyl)-acetamidine (0.062 mmol) in DMF (2 mL) was heated to 80° C. for 2 h. After cooling to room temperature, the reaction mixture was purified by reverse phase chromatography to yield 4-[2-(2,6-dichloro-benzyl)-3H-imidazol-4-yl]-N-methoxymethyl-N-thiazol-2-yl-benzenesulfonamide (0.003 mmol).

Provenance & Evidence