Ammonium Carbonate → HCID 67001458, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-acetyl-N-methoxymethyl-N-thiazol-2-yl-benzenesulfonamide (0.45 mmol), potassium cyanate (1.53 mmol), and ammonium carbonate (4.5 mmol) in ethanol and water (5 mL, 1:1) was stirred at 135° C. in a microwave reactor for 10 min. The reaction mixture was quenched with 6N HCl aqueous solution. After neutralized with saturated NaHCO3, the mixture was extracted with ethyl acetate. The organic phase was washed with brine, dried over MgSO4, and concentrated in vacuo. The crude product was purified by reverse phase HPLC to give 4-(2,5-dioxo-imidazolidin-4-yl)-N-methoxymethyl-N-thiazol-2-yl-benzenesulfonamide (0.2 mmol).

Provenance & Evidence