Hydrochloric Acid → HCID 178512758, compound

Participants

Reaction Steps

A solution of 4-(thiazol-2-ylsulfamoyl)-N-(3,4-dichloro-benzylideneamino)-benzamidine (0.387 mmol) and NaCNBH3 (large excess) was stirred in THF (5 mL) at room temperature. To the solution was added 6 N HCl drop wise until all starting material is consumed. The solution was quenched with sat NaHCO3 and extracted with ethyl acetate. The organic phase was collected and concentrated in vacuo. The crude product was purification by reverse phase chromatography to yield 4-(thiazol-2-ylsulfamoyl)-N-(3,4-dichlorobenzylamino)-benzamidine (0.09 mmol).

Provenance & Evidence