HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzylamine → HCID 59738291, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzylamine | HCID 66648 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 1-(Methoxycarbonyl)cyclopropane-1-carboxylic acid | HCID 13861823 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59738291 | HCID 59738291 | 35.2% |
Reaction Steps
To a solution of 1-(methoxycarbonyl)cyclopropanecarboxylic acid (500 mg, 3.5 mmol) in DMF (5 mL) were added HATU (1.98 g, 5.2 mmol, 1.5 equiv.) and 2-chlorobenzylamine (622 μL, 5.2 mmol, 1.5 equiv.). The reaction mixture was stirred for 2 h. The reaction mixture was purified twice on RP-HPLC using a mixture of acetonitrile and H2O to give methyl 1-(2-chlorobenzylcarbamoyl)cyclopropanecarboxylate (330 mg, 34%). LRMS (M+H+) m/z 268.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063082B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-e2ddd9e46c414453a6a6fdf74d39b444 |
| Source note | uspto-grants-2011_11 |