HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 178480364, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | 4-chloro-1-methyl-1H-pyrrole-2-carboxylic acid | HCID 9115266 | — |
| Reactant | HCID 178510438 | HCID 178510438 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178480364 | HCID 178480364 | 99.8% |
Reaction Steps
To a solution of 4-chloro-1-methyl-1H-pyrrole-2-carboxylic acid (55 mg, 0.34 mmol) and triethylamine (0.100 mL, 0.72 mmol) in DMF (2 mL), BOP (217 mg, 0.49 mmol) was added. After 5 min of stirring, a solution of 4-aminomethylimidazole 11-2 (100 mg, 1.03 mmol) in DMF (2 mL) was added. After being stirred at room temperature overnight, the mixture was purified by HPLC to give N-((1H-imidazol-4-yl)methyl)-4-chloro-1-methyl-1H-pyrrole-2-carboxamide (81 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063077B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-b24a328edf4e4bba805af7f9081f7fe8 |
| Source note | uspto-grants-2011_11 |