HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-(4-(aminomethyl)-1H-imidazol-1-yl)phenyl)pyridin-2(1H)-one hydrochloride → 1-(4-(4-(aminomethyl)-1H-imidazol-1-yl)phenyl)piperidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-(4-(aminomethyl)-1H-imidazol-1-yl)phenyl)pyridin-2(1H)-one hydrochloride | HCID 66974101 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(4-(4-(aminomethyl)-1H-imidazol-1-yl)phenyl)piperidin-2-one | HCID 66974092 | 99.9% |
Reaction Steps
A mixture of 1-(4-(4-(aminomethyl)-1H-imidazol-1-yl)phenyl)pyridin-2(1H)-one hydrochloride (60 mg, 0.20 mmol) and Pd—C (10%, 31 mg) in MeOH (6 mL) was hydrogenated under balloon H2 overnight. It was then filtered through celite. The filtrate was concentrated in vacuo to give 1-(4-(4-(aminomethyl)-1H-imidazol-1-yl)phenyl)piperidin-2-one (54 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063077B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-aa3b72f02a414a06b2670e8fa850de08 |
| Source note | uspto-grants-2011_11 |